| 1. Round | 06/08/2016 | Willem II | - | Vitesse | 1:4 | ||||
| 2. Round | 14/08/2016 | Heracles Almelo | - | Willem II | 3:1 | ||||
| 3. Round | 20/08/2016 | AFC Ajax | - | Willem II | 1:2 | ||||
| 4. Round | 27/08/2016 | Willem II | - | Roda JC Kerkrade | 0:0 | ||||
| 12. Round | 05/11/2016 | ADO Den Haag | - | Willem II | 1:0 | ||||
| 14. Round | 25/11/2016 | Go Ahead Eagles | - | Willem II | 0:1 | ||||
| 18. Round | 15/01/2017 | Willem II | - | NEC Nijmegen | 0:1 | ||||
| 21. Round | 04/02/2017 | Willem II | - | Heracles Almelo | 1:3 | ||||
| 23. Round | 19/02/2017 | Willem II | - | AZ Alkmaar | 1:1 | ||||
| 25. Round | 04/03/2017 | FC Twente | - | Willem II | 2:1 | ||||
| 28. Round | 01/04/2017 | FC Utrecht | - | Willem II | 2:0 |
Romania