| 1. Round | 18/07/2021 | Spartak Subotica | - | Radnički Niš | 1:1 | ||||
| 3. Round | 31/07/2021 | Spartak Subotica | - | Crvena Zvezda | 1:3 | ||||
| 4. Round | 07/08/2021 | Mladost Lučani | - | Spartak Subotica | 1:2 | ||||
| 5. Round | 16/08/2021 | Spartak Subotica | - | Vojvodina | 2:2 | ||||
| 6. Round | 22/08/2021 | Spartak Subotica | - | FK Napredak | 3:2 | ||||
| 7. Round | 28/08/2021 | Radnik Surdulica | - | Spartak Subotica | 1:2 | ||||
| 8. Round | 10/09/2021 | Spartak Subotica | - | TSC Bačka Topola | 0:0 | ||||
| 9. Round | 18/09/2021 | FK Čukarički | - | Spartak Subotica | 2:1 |  |
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| 10. Round | 22/09/2021 | Spartak Subotica | - | Proleter Novi Sad | 1:2 | ||||
| 18. Round | 28/11/2021 | Crvena Zvezda | - | Spartak Subotica | 3:0 | ||||
| 19. Round | 05/12/2021 | Spartak Subotica | - | Mladost Lučani | 0:0 | ||||
| 24. Round | 25/02/2022 | Spartak Subotica | - | FK Čukarički | 1:2 | ||||
| 25. Round | 01/03/2022 | Proleter Novi Sad | - | Spartak Subotica | 0:3 | |
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| 26. Round | 06/03/2022 | Spartak Subotica | - | Partizan | 0:1 | ||||
| 27. Round | 13/03/2022 | FK Voždovac | - | Spartak Subotica | 1:1 | |
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| 28. Round | 20/03/2022 | Spartak Subotica | - | FK Novi Pazar | 1:2 | ||||
| 29. Round | 02/04/2022 | FK Metalac | - | Spartak Subotica | 2:0 |
North Macedonia
Austria