| 3. Round | 27/07/2021 | Arsenal de Sarandí II | - | Argentinos Juniors II | 3:1 | ||||
| 9. Round | 30/08/2021 | Unión de Santa Fe II | - | Argentinos Juniors II | 1:2 | ||||
| 15. Round | 07/10/2021 | Argentinos Juniors II | - | Defensa y Justicia II | 0:0 | ||||
| 17. Round | 21/10/2021 | Argentinos Juniors II | - | Colón de Santa Fe II | 2:1 | ||||
| 18. Round | 26/10/2021 | River Plate II | - | Argentinos Juniors II | 0:3 | ||||
| 19. Round | 01/11/2021 | Argentinos Juniors II | - | Lanús II | 2:1 | ||||
| 20. Round | 09/11/2021 | Huracán II | - | Argentinos Juniors II | 1:0 | ||||
| 22. Round | 25/11/2021 | Vélez Sarsfield II | - | Argentinos Juniors II | 1:1 | ||||
| 23. Round | 30/11/2021 | Argentinos Juniors II | - | Gimnasia de La Plata II | 1:2 | ||||
| 24. Round | 04/12/2021 | Aldosivi II | - | Argentinos Juniors II | 2:2 |
Colombia