| 4. Round | 14/02/2022 | Bogotá FC | - | Valledupar FC | 2:1 | ||||
| 5. Round | 20/02/2022 | Valledupar FC | - | Orsomarso SC | 2:0 | ||||
| 6. Round | 26/02/2022 | Llaneros FC | - | Valledupar FC | 0:0 | ||||
| 7. Round | 07/03/2022 | Valledupar FC | - | Deportes Quindío | 0:0 |  |
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| 8. Round | 10/03/2022 | Boyacá Chicó | - | Valledupar FC | 2:2 |  |
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| 12. Round | 10/04/2022 | Valledupar FC | - | Fortaleza FC | 1:1 | ||||
| 13. Round | 16/04/2022 | Barranquilla FC | - | Valledupar FC | 1:1 | ||||
| 15. Round | 04/05/2022 | Real Cartagena | - | Valledupar FC | 1:2 |
Colombia