| 1. Round | 11/07/2022 | Deportes Tolima | - | Independiente Medellín | 1:1 |  |
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| 2. Round | 15/07/2022 | Independiente Medellín | - | Patriotas FC | 1:0 |  |
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| 3. Round | 22/07/2022 | Deportivo Cali | - | Independiente Medellín | 2:2 | ||||
| 10. Round | 05/09/2022 | Independiente Medellín | - | Atlético Nacional | 4:3 | |
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| 11. Round | 11/09/2022 | Independiente Medellín | - | América de Cali | 2:0 | ||||
| 13. Round | 23/09/2022 | Independiente Medellín | - | Deportivo Pereira | 2:1 | |
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| 14. Round | 25/09/2022 | Envigado FC | - | Independiente Medellín | 1:2 | |
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| 15. Round | 01/10/2022 | Independiente Medellín | - | Alianza Petrolera | 3:1 | |
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| 18. Round | 07/10/2022 | Atlético Nacional | - | Independiente Medellín | 3:2 | |
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| 16. Round | 10/10/2022 | Unión Magdalena | - | Independiente Medellín | 0:2 | ||||
| 17. Round | 20/10/2022 | Independiente Medellín | - | Atlético Bucaramanga | 1:2 | ||||
| 19. Round | 23/10/2022 | Independiente Medellín | - | Jaguares de Córdoba | 0:0 | |
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| 20. Round | 30/10/2022 | Deportivo Pasto | - | Independiente Medellín | 0:0 | |
Colombia