| 1. Round | 22/07/2012 | Santos Laguna | - | Club San Luis | 2:1 | ||||
| 2. Round | 29/07/2012 | Club San Luis | - | Cruz Azul | 1:2 |  |
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| 3. Round | 04/08/2012 | Monarcas Morelia | - | Club San Luis | 3:3 | |
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| 4. Round | 12/08/2012 | Club San Luis | - | CF Monterrey | 1:1 | |
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| 5. Round | 19/08/2012 | Club San Luis | - | Deportivo Guadalajara | 0:1 | ||||
| 6. Round | 26/08/2012 | Puebla FC | - | Club San Luis | 1:0 | ||||
| 7. Round | 02/09/2012 | Club San Luis | - | Club León | 0:2 | ||||
| 8. Round | 16/09/2012 | Pumas UNAM | - | Club San Luis | 0:1 | ||||
| 9. Round | 23/09/2012 | Club San Luis | - | CF Pachuca | 1:0 | |
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| 10. Round | 30/09/2012 | UANL Tigres | - | Club San Luis | 0:0 | ||||
| 11. Round | 03/10/2012 | Club San Luis | - | CF América | 1:2 | ||||
| 12. Round | 07/10/2012 | Jaguares Chiapas | - | Club San Luis | 4:0 | ||||
| 13. Round | 14/10/2012 | Club San Luis | - | Atlante | 2:2 | ||||
| 14. Round | 21/10/2012 | Atlas Guadalajara | - | Club San Luis | 2:3 | ||||
| 15. Round | 27/10/2012 | Club San Luis | - | Gallos Blancos (old) | 0:0 | |
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| 16. Round | 04/11/2012 | Club Tijuana | - | Club San Luis | 0:0 | |
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| 17. Round | 11/11/2012 | Club San Luis | - | Deportivo Toluca | 0:2 |
Colombia