| 1. Round | 16/07/2021 | Sepsi OSK | - | Academica Clinceni | 2:0 | ||||
| 3. Round | 02/08/2021 | Sepsi OSK | - | CS Mioveni | 1:2 | ||||
| 4. Round | 09/08/2021 | Farul Constanța | - | Sepsi OSK | 1:0 | ||||
| 5. Round | 15/08/2021 | Sepsi OSK | - | Argeș Pitești | 0:2 | ||||
| 6. Round | 23/08/2021 | FCSB | - | Sepsi OSK | 1:1 | ||||
| 7. Round | 29/08/2021 | Sepsi OSK | - | FC Botoşani | 1:1 |  |
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| 8. Round | 13/09/2021 | CS Universitatea Craiova | - | Sepsi OSK | 1:1 |  |
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| 14. Round | 31/10/2021 | Sepsi OSK | - | Dinamo Bucureşti | 4:1 | ||||
| 15. Round | 06/11/2021 | FC Universitatea Craiova | - | Sepsi OSK | 1:1 | ||||
| 18. Round | 05/12/2021 | CS Mioveni | - | Sepsi OSK | 0:2 | ||||
| 19. Round | 12/12/2021 | Sepsi OSK | - | Farul Constanța | 1:0 | ||||
| 20. Round | 15/12/2021 | Argeș Pitești | - | Sepsi OSK | 1:1 | |
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| 21. Round | 19/12/2021 | Sepsi OSK | - | FCSB | 0:0 | ||||
| 25. Round | 08/02/2022 | Sepsi OSK | - | Gaz Metan Mediaş | 2:0 | ||||
| 26. Round | 11/02/2022 | Rapid Bucureşti | - | Sepsi OSK | 1:1 | ||||
| 27. Round | 19/02/2022 | FC Voluntari | - | Sepsi OSK | 3:1 | |
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| 28. Round | 26/02/2022 | Sepsi OSK | - | CFR Cluj | 0:2 | ||||
| 29. Round | 01/03/2022 | Dinamo Bucureşti | - | Sepsi OSK | 1:3 | |
Romania