| 5. Round | 06/02/2022 | Millonarios | - | Unión Magdalena | 1:0 | ||||
| 6. Round | 11/02/2022 | Unión Magdalena | - | Envigado FC | 2:1 | ||||
| 9. Round | 27/02/2022 | Unión Magdalena | - | Deportivo Cali | 0:2 | ||||
| 10. Round | 05/03/2022 | Atlético Junior | - | Unión Magdalena | 3:1 |  |
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| 11. Round | 18/03/2022 | Unión Magdalena | - | Cortuluá | 0:2 | ||||
| 12. Round | 21/03/2022 | Jaguares de Córdoba | - | Unión Magdalena | 2:0 | |
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| 13. Round | 26/03/2022 | Unión Magdalena | - | Águilas Doradas | 2:1 | |
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| 14. Round | 04/04/2022 | Santa Fe | - | Unión Magdalena | 1:0 | |
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| 15. Round | 10/04/2022 | Unión Magdalena | - | Patriotas FC | 0:1 | |
Colombia