| 1. Round | 26/07/2021 | Unión Magdalena | - | Fortaleza FC | 3:1 | ||||
| 2. Round | 31/07/2021 | Real Santander | - | Unión Magdalena | 3:3 | ||||
| 3. Round | 10/08/2021 | Unión Magdalena | - | Cortuluá | 2:0 | ||||
| 7. Round | 04/09/2021 | Leones FC | - | Unión Magdalena | 3:0 | ||||
| 8. Round | 12/09/2021 | Unión Magdalena | - | Llaneros FC | 1:1 | ||||
| 9. Round | 22/09/2021 | Tigres FC | - | Unión Magdalena | 0:0 | ||||
| 13. Round | 18/10/2021 | Orsomarso SC | - | Unión Magdalena | 1:2 |  |
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| 14. Round | 24/10/2021 | Unión Magdalena | - | Valledupar FC | 3:1 | |
Colombia