| 3. Round | 18/09/2021 | UD Melilla | - | Recreativo Granada | 1:3 |  |
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| 4. Round | 26/09/2021 | CF Intercity | - | UD Melilla | 0:0 | ||||
| 5. Round | 03/10/2021 | UD Melilla | - | Mar Menor CF | 2:3 | ||||
| 6. Round | 10/10/2021 | UD Alzira | - | UD Melilla | 0:1 |  |
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| 7. Round | 17/10/2021 | UD Melilla | - | UD Socuéllamos | 3:1 | |
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| 8. Round | 24/10/2021 | CA Pulpileño | - | UD Melilla | 1:3 | ||||
| 11. Round | 14/11/2021 | UD Melilla | - | CF La Nucía | 1:0 | ||||
| 12. Round | 21/11/2021 | CD Eldense | - | UD Melilla | 2:1 | ||||
| 13. Round | 28/11/2021 | UD Melilla | - | Hércules CF | 1:2 | ||||
| 14. Round | 05/12/2021 | Real Murcia | - | UD Melilla | 0:0 | ||||
| 15. Round | 12/12/2021 | CS Puertollano CF | - | UD Melilla | 1:0 | ||||
| 18. Round | 23/01/2022 | CD Toledo | - | UD Melilla | 2:0 |
Spain