| 1. Round | 21/07/2022 | Guadalupe | - | Sporting FC | 1:2 | ||||
| 2. Round | 24/07/2022 | CS Herediano | - | Guadalupe | 1:0 | ||||
| 3. Round | 31/07/2022 | Santos de Guápiles | - | Guadalupe | 3:3 | ||||
| 4. Round | 07/08/2022 | Guadalupe | - | LD Alajuelense | 1:3 | ||||
| 5. Round | 11/08/2022 | AD Guanacasteca | - | Guadalupe | 1:2 | ||||
| 8. Round | 28/08/2022 | Guadalupe | - | Santos de Guápiles | 3:0 | ||||
| 11. Round | 11/09/2022 | Municipal Pérez Zeledón | - | Guadalupe | 2:1 | ||||
| 12. Round | 18/09/2022 | CS Cartaginés | - | Guadalupe | 3:0 | ||||
| 13. Round | 22/09/2022 | Guadalupe | - | AD San Carlos | 2:1 | ||||
| 14. Round | 25/09/2022 | Guadalupe | - | Municipal Grecia | 0:1 | ||||
| 15. Round | 29/09/2022 | Puntarenas FC | - | Guadalupe | 0:2 |  |
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| 16. Round | 03/10/2022 | Guadalupe | - | Deportivo Saprissa | 1:2 |
Costa Rica