| 8. Round | 05/09/2010 | Deportes Tolima | - | Santa Fe | 1:2 | ||||
| 10. Round | 19/09/2010 | Santa Fe | - | Millonarios | 2:0 |  |
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| 11. Round | 26/09/2010 | Atlético Nacional | - | Santa Fe | 0:1 | ||||
| 12. Round | 02/10/2010 | Santa Fe | - | Deportivo Cali | 1:1 | |
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| 15. Round | 24/10/2010 | Cúcuta Deportivo | - | Santa Fe | 1:1 | ||||
| 16. Round | 31/10/2010 | Santa Fe | - | Once Caldas | 1:1 | |
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| 17. Round | 06/11/2010 | Boyacá Chicó | - | Santa Fe | 2:0 |
Colombia