| Group B | 15/09/2010 | Columbus Crew | - | Joe Public FC | 3:0 | ||||
| Group B | 22/09/2010 | Columbus Crew | - | Santos Laguna | 1:0 |  |
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| Group B | 30/09/2010 | CSD Municipal | - | Columbus Crew | 2:1 | ||||
| Group B | 22/10/2010 | Joe Public FC | - | Columbus Crew | 1:4 | |
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| Quarter-finals | 23/02/2011 | Columbus Crew | - | Real Salt Lake | 0:0 | ||||
| Quarter-finals | 02/03/2011 | Real Salt Lake | - | Columbus Crew | 4:1 | |
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Peru