| 1. Round | 24/01/2020 | Deportes Tolima | - | Independiente Medellín | 2:2 |  |
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| 3. Round | 01/02/2020 | Atlético Bucaramanga | - | Deportes Tolima | 0:0 | ||||
| 4. Round | 08/02/2020 | Deportes Tolima | - | Envigado FC | 3:0 | ||||
| 5. Round | 14/02/2020 | Águilas Doradas | - | Deportes Tolima | 1:1 | |
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| 6. Round | 23/02/2020 | Deportes Tolima | - | Atlético Junior | 0:0 | ||||
| 8. Round | 09/03/2020 | Deportes Tolima | - | Patriotas FC | 1:0 | ||||
| 2. Round | 14/09/2020 | Deportivo Pasto | - | Deportes Tolima | 1:3 | ||||
| 10. Round | 27/09/2020 | Deportes Tolima | - | América de Cali | 1:0 | ||||
| 9. Round | 01/10/2020 | Atlético Nacional | - | Deportes Tolima | 1:2 | |
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| 11. Round | 04/10/2020 | Deportivo Pereira | - | Deportes Tolima | 0:0 | ||||
| 12. Round | 07/10/2020 | Deportes Tolima | - | Millonarios | 2:2 | |
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| 13. Round | 11/10/2020 | Cúcuta Deportivo | - | Deportes Tolima | 0:3 | |
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| 14. Round | 15/10/2020 | Deportes Tolima | - | Alianza Petrolera | 3:1 | ||||
| 15. Round | 18/10/2020 | Jaguares de Córdoba | - | Deportes Tolima | 1:1 | |
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| 16. Round | 25/10/2020 | Deportes Tolima | - | La Equidad | 1:2 | |
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| 17. Round | 01/11/2020 | Deportivo Cali | - | Deportes Tolima | 1:2 | ||||
| 19. Round | 11/11/2020 | Santa Fe | - | Deportes Tolima | 1:0 |
Colombia