| 1. Round | 19/07/2021 | Deportes Tolima | - | Deportivo Pereira | 1:0 | ||||
| 2. Round | 25/07/2021 | Atlético Nacional | - | Deportes Tolima | 1:0 |  |
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| 3. Round | 31/07/2021 | Deportes Tolima | - | Alianza Petrolera | 1:1 | ||||
| 4. Round | 09/08/2021 | Atlético Junior | - | Deportes Tolima | 0:0 | |
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| 5. Round | 14/08/2021 | Deportes Tolima | - | Deportivo Pasto | 1:0 |  |
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| 6. Round | 22/08/2021 | La Equidad | - | Deportes Tolima | 1:1 | |
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| 7. Round | 30/08/2021 | Jaguares de Córdoba | - | Deportes Tolima | 0:3 | |
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| 17. Round | 03/11/2021 | Águilas Doradas | - | Deportes Tolima | 1:1 | |
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| 18. Round | 07/11/2021 | Deportes Tolima | - | Millonarios | 3:2 | ||||
| 19. Round | 15/11/2021 | Atlético Bucaramanga | - | Deportes Tolima | 1:1 |
Colombia