| 8. Round | 14/04/2022 | Zulia FC | - | Universidad Central | 2:2 |  |
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| 9. Round | 24/04/2022 | Mineros de Guayana | - | Zulia FC | 0:3 | |
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| 10. Round | 28/04/2022 | Zulia FC | - | Zamora FC | 0:2 | ||||
| 12. Round | 15/05/2022 | Zulia FC | - | Estudiantes de Mérida | 3:2 | ||||
| 13. Round | 21/05/2022 | Zulia FC | - | Caracas FC | 1:0 | |
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| 14. Round | 26/05/2022 | Hermanos Colmenarez | - | Zulia FC | 0:2 | |
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| 16. Round | 11/06/2022 | Academia Puerto Cabello | - | Zulia FC | 2:2 | ||||
| 17. Round | 17/06/2022 | Zulia FC | - | Hermanos Colmenarez | 2:1 | |
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| 21. Round | 25/07/2022 | Zamora FC | - | Zulia FC | 5:1 | ||||
| 22. Round | 29/07/2022 | Zulia FC | - | Mineros de Guayana | 1:1 | |
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| 23. Round | 07/08/2022 | Universidad Central | - | Zulia FC | 0:1 | |
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| 24. Round | 11/08/2022 | Zulia FC | - | Monagas | 0:0 | ||||
| 25. Round | 18/08/2022 | Zulia FC | - | Aragua FC | 0:0 | ||||
| 26. Round | 25/08/2022 | Deportivo La Guaira | - | Zulia FC | 2:1 | |
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| 28. Round | 08/09/2022 | Metropolitanos FC | - | Zulia FC | 2:0 | |
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| 29. Round | 14/09/2022 | Zulia FC | - | Deportivo Táchira | 1:3 | |
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| 30. Round | 18/09/2022 | Deportivo Lara | - | Zulia FC | 3:0 |
Venezuela