1. Round | 01/08/2021 | Xelaju MC | - | Cobán Imperial | 3:0 | ||||
4. Round | 14/08/2021 | Cobán Imperial | - | Achuapa | 2:0 | ||||
5. Round | 22/08/2021 | Comunicaciones | - | Cobán Imperial | 2:2 | ||||
6. Round | 25/08/2021 | Deportivo Malacateco | - | Cobán Imperial | 1:0 | ||||
7. Round | 29/08/2021 | Cobán Imperial | - | Antigua GFC | 0:2 | ||||
9. Round | 11/09/2021 | Cobán Imperial | - | Santa Lucía | 0:1 | ||||
10. Round | 18/09/2021 | CSD Municipal | - | Cobán Imperial | 2:1 | ||||
11. Round | 25/09/2021 | Cobán Imperial | - | Iztapa | 2:1 | ||||
12. Round | 02/10/2021 | Cobán Imperial | - | Xelaju MC | 1:1 | ||||
13. Round | 10/10/2021 | Sololá FC | - | Cobán Imperial | 1:2 | ||||
14. Round | 17/10/2021 | Cobán Imperial | - | Nueva Concepción | 2:0 | ||||
15. Round | 23/10/2021 | Achuapa | - | Cobán Imperial | 1:0 | ||||
16. Round | 27/10/2021 | Cobán Imperial | - | Comunicaciones | 1:2 | ||||
17. Round | 31/10/2021 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
18. Round | 07/11/2021 | Antigua GFC | - | Cobán Imperial | 2:1 | ||||
19. Round | 13/11/2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 | ||||
20. Round | 20/11/2021 | Santa Lucía | - | Cobán Imperial | 2:2 | ||||
21. Round | 28/11/2021 | Cobán Imperial | - | CSD Municipal | 0:1 |