| Group 2 | 21/02/2021 | Santa Tecla FC | - | AD Chalatenango | 3:2 | ||||
| Group B | 07/04/2021 | CD Águila | - | Santa Tecla FC | 0:0 | ||||
| Group B | 11/04/2021 | Santa Tecla FC | - | Sonsonate FC | 3:1 | ||||
| Group B | 22/04/2021 | Santa Tecla FC | - | Isidro Metapán | 3:1 | ||||
| Group B | 25/04/2021 | AD Chalatenango | - | Santa Tecla FC | 1:1 | ||||
| Group B | 28/04/2021 | Santa Tecla FC | - | CD Águila | 1:1 | ||||
| Group B | 01/05/2021 | Sonsonate FC | - | Santa Tecla FC | 2:1 | ||||
| Quarter-finals | 06/05/2021 | Santa Tecla FC | - | Once Municipal | 1:1 |  |
El Salvador