| 2. Round | 15/07/2022 | Deportivo Municipal | - | Cienciano | 0:0 |  |
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| 3. Round | 24/07/2022 | AD Tarma | - | Cienciano | 0:1 | |
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| 4. Round | 27/07/2022 | Cienciano | - | Deportivo Binacional | 1:1 | ||||
| 5. Round | 30/07/2022 | Ayacucho FC | - | Cienciano | 0:1 | |
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| 10. Round | 03/09/2022 | Cienciano | - | Mannucci | 2:0 | ||||
| 11. Round | 11/09/2022 | Sporting Cristal | - | Cienciano | 4:1 | |
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| 12. Round | 17/09/2022 | Cienciano | - | FBC Melgar | 2:2 | ||||
| 14. Round | 04/10/2022 | Cienciano | - | Sport Huancayo | 0:1 | |
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| 15. Round | 07/10/2022 | Universidad Técnica | - | Cienciano | 2:1 | |
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| 19. Round | 30/10/2022 | Universidad San Martín | - | Cienciano | 1:2 |  |
Peru