| 1. Round | 08/08/2008 | FC Zwolle | - | MVV | 0:0 |  |
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| 2. Round | 15/08/2008 | MVV | - | SBV Excelsior | 0:1 | ||||
| 3. Round | 22/08/2008 | MVV | - | Helmond Sport | 3:1 |  |
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| 4. Round | 29/08/2008 | FC Den Bosch | - | MVV | 1:3 | ||||
| 5. Round | 05/09/2008 | MVV | - | Go Ahead Eagles | 1:1 | |
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| 6. Round | 12/09/2008 | RBC Roosendaal | - | MVV | 1:1 | ||||
| 7. Round | 15/09/2008 | MVV | - | FC Eindhoven | 3:1 | ||||
| 8. Round | 19/09/2008 | TOP Oss | - | MVV | 1:0 | ||||
| 9. Round | 27/09/2008 | FC Emmen | - | MVV | 1:1 | ||||
| 10. Round | 03/10/2008 | MVV | - | BV Veendam | 1:2 | ||||
| 11. Round | 10/10/2008 | MVV | - | Telstar | 2:0 | |
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| 12. Round | 17/10/2008 | FC Dordrecht | - | MVV | 1:1 | |
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| 13. Round | 24/10/2008 | MVV | - | FC Omniworld | 2:1 | ||||
| 14. Round | 31/10/2008 | AGOVV | - | MVV | 2:3 | ||||
| 15. Round | 07/11/2008 | MVV | - | Fortuna Sittard | 0:2 | ||||
| 16. Round | 15/11/2008 | SC Cambuur | - | MVV | 2:1 | |
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| 18. Round | 28/11/2008 | MVV | - | RKC Waalwijk | 2:1 | ||||
| 20. Round | 12/12/2008 | MVV | - | FC Zwolle | 4:1 | |
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| 38. Round | 08/05/2009 | MVV | - | AGOVV | 3:1 | |
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