| 1. Round | 29/07/2018 | Sporting Lokeren | - | KRC Genk | 0:4 | ||||
| 2. Round | 04/08/2018 | Cercle Brugge | - | Sporting Lokeren | 3:2 | ||||
| 3. Round | 11/08/2018 | Sint-Truidense VV | - | Sporting Lokeren | 1:1 |  |
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| 4. Round | 18/08/2018 | Sporting Lokeren | - | Standard Liège | 0:3 | ||||
| 5. Round | 26/08/2018 | KAA Gent | - | Sporting Lokeren | 2:1 | ||||
| 7. Round | 14/09/2018 | Club Brugge KV | - | Sporting Lokeren | 2:1 | ||||
| 9. Round | 29/09/2018 | Sporting Charleroi | - | Sporting Lokeren | 2:1 | ||||
| 12. Round | 27/10/2018 | Sporting Lokeren | - | KV Oostende | 0:0 | ||||
| 13. Round | 01/11/2018 | RSC Anderlecht | - | Sporting Lokeren | 1:1 | ||||
| 14. Round | 04/11/2018 | Sporting Lokeren | - | KAS Eupen | 2:0 | ||||
| 16. Round | 25/11/2018 | Sporting Lokeren | - | Sporting Charleroi | 2:4 | ||||
| 18. Round | 08/12/2018 | KV Oostende | - | Sporting Lokeren | 1:0 | ||||
| 20. Round | 22/12/2018 | Waasland-Beveren | - | Sporting Lokeren | 2:1 | ||||
| 24. Round | 02/02/2019 | KV Kortrijk | - | Sporting Lokeren | 2:1 |  |
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| 25. Round | 09/02/2019 | Sporting Lokeren | - | Royal Antwerp FC | 2:1 | ||||
| 27. Round | 23/02/2019 | Royal Excel Mouscron | - | Sporting Lokeren | 1:0 | ||||
| 28. Round | 03/03/2019 | Sporting Lokeren | - | RSC Anderlecht | 1:2 |
Belarus