2. Round | 03/08/2021 | Boyacá Chicó | - | Real Cartagena | 1:0 | ||||
3. Round | 06/08/2021 | Real Cartagena | - | Fortaleza FC | 0:1 | ||||
4. Round | 14/08/2021 | Real Santander | - | Real Cartagena | 2:2 | ||||
5. Round | 25/08/2021 | Real Cartagena | - | Cortuluá | 2:0 | ||||
7. Round | 04/09/2021 | Real Cartagena | - | Boca Juniors de Cali | 2:0 |