| 17. Round | 12/08/2021 | Jiangxi Beidamen | - | Guizhou FC | 0:1 | ||||
| 18. Round | 17/08/2021 | Guizhou FC | - | Nanjing City | 1:2 |  |
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| 19. Round | 05/09/2021 | Nantong Zhiyun | - | Guizhou FC | 0:1 |  |
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| 21. Round | 13/09/2021 | Zibo Cuju | - | Guizhou FC | 0:1 | |
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| 22. Round | 17/09/2021 | Guizhou FC | - | Beijing BSU | 0:0 | ||||
| 23. Round | 21/09/2021 | Guizhou FC | - | Nantong Zhiyun | 0:2 | ||||
| 24. Round | 26/09/2021 | Xinjiang Tianshan Leopard | - | Guizhou FC | 1:1 | ||||
| 25. Round | 30/09/2021 | Guizhou FC | - | Zibo Cuju | 1:2 | ||||
| 26. Round | 04/10/2021 | Beijing BSU | - | Guizhou FC | 1:1 | ||||
| 27. Round | 22/11/2021 | Meizhou Hakka | - | Guizhou FC | 4:2 | ||||
| 28. Round | 25/11/2021 | Guizhou FC | - | Zhejiang Professional | 0:0 | ||||
| 29. Round | 29/11/2021 | Guizhou FC | - | Kunshan FC | 0:4 |
China