| 1. Round | 17/04/2021 | Caracas FC | - | Universidad Central | 2:0 | ||||
| 2. Round | 25/04/2021 | Universidad Central | - | Monagas | 0:2 |  |
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| 5. Round | 15/05/2021 | Universidad Central | - | LALA FC | 2:0 | ||||
| 6. Round | 24/05/2021 | Metropolitanos FC | - | Universidad Central | 3:2 | ||||
| 14. Round | 15/07/2021 | Universidad Central | - | Mineros de Guayana | 1:0 | ||||
| 15. Round | 25/07/2021 | Caracas FC | - | Universidad Central | 2:1 | ||||
| 19. Round | 20/08/2021 | Universidad Central | - | LALA FC | 1:0 | |
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| 20. Round | 29/08/2021 | Metropolitanos FC | - | Universidad Central | 1:1 | ||||
| 21. Round | 03/09/2021 | Mineros de Guayana | - | Universidad Central | 1:1 | ||||
| 22. Round | 08/09/2021 | Universidad Central | - | Caracas FC | 1:1 | ||||
| 23. Round | 16/09/2021 | Monagas | - | Universidad Central | 2:1 | |
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| 24. Round | 24/09/2021 | Universidad Central | - | Atlético Venezuela | 4:0 | ||||
| 26. Round | 05/10/2021 | LALA FC | - | Universidad Central | 0:1 | ||||
| 27. Round | 15/10/2021 | Universidad Central | - | Metropolitanos FC | 1:1 |  |
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| 28. Round | 21/10/2021 | Universidad Central | - | Mineros de Guayana | 4:1 | |
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Venezuela