| 1. Round | 05/02/2022 | Alianza Lima | - | Atlético Grau | 1:1 | ||||
| 2. Round | 13/02/2022 | Sport Boys | - | Alianza Lima | 0:0 | ||||
| 3. Round | 20/02/2022 | Alianza Lima | - | Mannucci | 3:1 | ||||
| 4. Round | 27/02/2022 | Alianza Atlético | - | Alianza Lima | 4:2 | ||||
| 5. Round | 06/03/2022 | Alianza Lima | - | Sporting Cristal | 0:1 |  |
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| 6. Round | 12/03/2022 | FBC Melgar | - | Alianza Lima | 1:0 | |
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| 9. Round | 10/04/2022 | Alianza Lima | - | Universidad Técnica | 1:0 | ||||
| 10. Round | 17/04/2022 | Universitario de Deportes | - | Alianza Lima | 1:4 |  |
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| 11. Round | 23/04/2022 | Academia Cantolao | - | Alianza Lima | 1:2 | ||||
| 13. Round | 09/05/2022 | Universidad San Martín | - | Alianza Lima | 0:1 | ||||
| 14. Round | 15/05/2022 | Alianza Lima | - | Universidad Cesar Vallejo | 2:0 | ||||
| 15. Round | 22/05/2022 | Deportivo Municipal | - | Alianza Lima | 0:3 | ||||
| 16. Round | 31/05/2022 | Alianza Lima | - | Cienciano | 1:0 | ||||
| 8. Round | 05/06/2022 | Sport Huancayo | - | Alianza Lima | 2:0 |
Colombia