| 1. Round | 06/01/2022 | Alebrijes de Oaxaca | - | Cancún FC | 2:0 | ||||
| 2. Round | 12/01/2022 | TM Fútbol Club | - | Alebrijes de Oaxaca | 1:1 | ||||
| 3. Round | 20/01/2022 | Alebrijes de Oaxaca | - | Leones Negros | 1:1 |  |
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| 4. Round | 26/01/2022 | CF Monterrey II | - | Alebrijes de Oaxaca | 2:0 | ||||
| 5. Round | 29/01/2022 | Alebrijes de Oaxaca | - | Atlético Morelia | 1:1 | ||||
| 8. Round | 17/02/2022 | Cimarrones de Sonora | - | Alebrijes de Oaxaca | 0:1 | ||||
| 9. Round | 22/02/2022 | Mineros de Zacatecas | - | Alebrijes de Oaxaca | 4:2 |  |
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| 10. Round | 01/03/2022 | Alebrijes de Oaxaca | - | Club Celaya | 1:0 | |
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| 12. Round | 16/03/2022 | Alebrijes de Oaxaca | - | Coyotes de Tlaxcala | 2:1 | ||||
| 13. Round | 22/03/2022 | Tapatío | - | Alebrijes de Oaxaca | 0:1 | ||||
| 14. Round | 27/03/2022 | Alebrijes de Oaxaca | - | Dorados de Sinaloa | 5:1 | |
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| 15. Round | 30/03/2022 | Atlante | - | Alebrijes de Oaxaca | 1:0 | ||||
| 16. Round | 05/04/2022 | Alebrijes de Oaxaca | - | Pumas Tabasco | 0:0 | ||||
| 17. Round | 13/04/2022 | Correcaminos UAT | - | Alebrijes de Oaxaca | 0:1 | |
Mexico