| 1. Round | 20/01/2022 | Victoria | - | Real España | 4:1 | ||||
| 2. Round | 23/01/2022 | Victoria | - | Real Sociedad | 2:0 | ||||
| 3. Round | 06/02/2022 | Platense | - | Victoria | 0:2 |  |
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| 6. Round | 19/02/2022 | Marathón | - | Victoria | 2:3 | ||||
| 7. Round | 27/02/2022 | Victoria | - | Vida | 1:2 | ||||
| 8. Round | 04/03/2022 | Honduras Progreso | - | Victoria | 2:1 | ||||
| 11. Round | 20/03/2022 | Real Sociedad | - | Victoria | 1:3 | ||||
| 12. Round | 03/04/2022 | Victoria | - | Motagua | 1:0 | |
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| 13. Round | 07/04/2022 | Lobos UPNFM | - | Victoria | 0:3 | ||||
| 14. Round | 10/04/2022 | Victoria | - | Marathón | 0:1 | ||||
| 16. Round | 21/04/2022 | Real España | - | Victoria | 3:1 | |
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| 17. Round | 24/04/2022 | Vida | - | Victoria | 1:1 | |
Honduras