| 1. Round | 13/03/2021 | Energetik-BGU Minsk | - | FK Smorgon | 3:0 | ||||
| 2. Round | 20/03/2021 | Energetik-BGU Minsk | - | Shakhter Soligorsk | 1:2 | ||||
| 3. Round | 04/04/2021 | Rukh Brest | - | Energetik-BGU Minsk | 0:0 | ||||
| 20. Round | 22/08/2021 | Energetik-BGU Minsk | - | BATE Borisov | 1:1 | ||||
| 21. Round | 29/08/2021 | Neman Grodno | - | Energetik-BGU Minsk | 3:0 | ||||
| 23. Round | 17/09/2021 | Torpedo-BelAZ Zhodino | - | Energetik-BGU Minsk | 0:1 | ||||
| 24. Round | 26/09/2021 | Energetik-BGU Minsk | - | FK Vitebsk | 2:2 | ||||
| 27. Round | 23/10/2021 | FK Gomel | - | Energetik-BGU Minsk | 4:0 | ||||
| 28. Round | 06/11/2021 | Energetik-BGU Minsk | - | FK Minsk | 1:1 | ||||
| 29. Round | 20/11/2021 | Energetik-BGU Minsk | - | FK Slaviya Mozyr | 2:3 | ||||
| 30. Round | 28/11/2021 | FK Isloch Minsk | - | Energetik-BGU Minsk | 0:4 |  |
Belarus