| 1. Round | 25/07/2021 | Lokomotiv Plovdiv | - | PFC Ludogorets Razgrad | 1:3 | ||||
| 2. Round | 01/08/2021 | Lokomotiv Sofia | - | Lokomotiv Plovdiv | 1:0 | ||||
| 4. Round | 16/08/2021 | Cherno More Varna | - | Lokomotiv Plovdiv | 0:0 | ||||
| 5. Round | 22/08/2021 | Lokomotiv Plovdiv | - | Slavia Sofia | 0:1 | ||||
| 6. Round | 28/08/2021 | Botev Vratsa | - | Lokomotiv Plovdiv | 0:0 | ||||
| 7. Round | 12/09/2021 | Lokomotiv Plovdiv | - | Levski Sofia | 2:2 | ||||
| 8. Round | 17/09/2021 | Tsarsko Selo Sofia | - | Lokomotiv Plovdiv | 0:2 | ||||
| 9. Round | 25/09/2021 | Lokomotiv Plovdiv | - | Botev Plovdiv | 1:1 |  |
|||
| 10. Round | 01/10/2021 | PFC Beroe | - | Lokomotiv Plovdiv | 1:0 | ||||
| 12. Round | 22/10/2021 | Lokomotiv Plovdiv | - | CSKA 1948 Sofia | 2:1 | ||||
| 13. Round | 31/10/2021 | CSKA Sofia | - | Lokomotiv Plovdiv | 1:3 | ||||
| 15. Round | 21/11/2021 | Lokomotiv Plovdiv | - | Lokomotiv Sofia | 2:1 | |
|||
| 16. Round | 27/11/2021 | Pirin Blagoevgrad | - | Lokomotiv Plovdiv | 2:3 |
Moldova
Romania