| 1. Round | 26/07/2021 | Wisła Kraków | - | Zagłębie Lubin | 3:0 |  |
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| 2. Round | 31/07/2021 | Bruk-Bet Termalica Nieciecza | - | Wisła Kraków | 2:2 | ||||
| 3. Round | 08/08/2021 | Wisła Kraków | - | Raków Częstochowa | 1:2 | ||||
| 4. Round | 13/08/2021 | FKS Stal Mielec | - | Wisła Kraków | 2:1 | |
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| 5. Round | 21/08/2021 | Górnik Łęczna | - | Wisła Kraków | 1:3 | ||||
| 6. Round | 29/08/2021 | Wisła Kraków | - | Legia Warszawa | 1:0 | ||||
| 7. Round | 12/09/2021 | Wisła Kraków | - | Lechia Gdańsk | 2:2 | ||||
| 8. Round | 17/09/2021 | Lech Poznań | - | Wisła Kraków | 5:0 | |
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| 9. Round | 26/09/2021 | Wisła Kraków | - | Pogoń Szczecin | 0:1 | ||||
| 10. Round | 01/10/2021 | Piast Gliwice | - | Wisła Kraków | 1:0 | |
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| 14. Round | 07/11/2021 | Wisła Kraków | - | KS Cracovia | 1:0 | |
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| 15. Round | 20/11/2021 | Jagiellonia Białystok | - | Wisła Kraków | 3:1 | ||||
| 16. Round | 26/11/2021 | Wisła Kraków | - | Radomiak Radom | 0:1 | ||||
| 17. Round | 06/12/2021 | Warta Poznań | - | Wisła Kraków | 1:1 | ||||
| 18. Round | 11/12/2021 | Zagłębie Lubin | - | Wisła Kraków | 2:1 | |
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| 19. Round | 17/12/2021 | Wisła Kraków | - | Bruk-Bet Termalica Nieciecza | 3:0 |  |
Netherlands
Morocco