| 1. Round | 05/08/2022 | FC Den Bosch | - | FC Eindhoven | 1:3 | ||||
| 2. Round | 14/08/2022 | ADO Den Haag | - | FC Den Bosch | 0:2 |  |
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| 3. Round | 19/08/2022 | FC Den Bosch | - | Roda JC Kerkrade | 0:3 | ||||
| 4. Round | 26/08/2022 | Almere City FC | - | FC Den Bosch | 2:0 | ||||
| 5. Round | 02/09/2022 | FC Den Bosch | - | PEC Zwolle | 1:2 | ||||
| 6. Round | 09/09/2022 | FC Dordrecht | - | FC Den Bosch | 2:1 | ||||
| 8. Round | 12/09/2022 | Jong PSV | - | FC Den Bosch | 3:1 | ||||
| 7. Round | 17/09/2022 | FC Den Bosch | - | TOP Oss | 4:1 | ||||
| 9. Round | 30/09/2022 | FC Den Bosch | - | Heracles Almelo | 1:2 | ||||
| 11. Round | 14/10/2022 | FC Den Bosch | - | AZ Alkmaar (J) | 3:0 | ||||
| 15. Round | 14/11/2022 | Jong Ajax | - | FC Den Bosch | 4:4 | ||||
| 16. Round | 19/11/2022 | FC Den Bosch | - | VVV-Venlo | 0:2 | ||||
| 17. Round | 11/12/2022 | Telstar | - | FC Den Bosch | 1:0 |
Spain