| 1. Round | 18/09/2021 | SS Folgore/Falciano | - | FC Domagnano | 0:1 | ||||
| 2. Round | 25/09/2021 | FC Domagnano | - | SP Cailungo | 3:0 | ||||
| 3. Round | 03/10/2021 | FC Domagnano | - | FC Fiorentino | 3:0 | ||||
| 4. Round | 16/10/2021 | SS Virtus | - | FC Domagnano | 1:2 | ||||
| 9. Round | 20/11/2021 | SS Murata | - | FC Domagnano | 2:0 | ||||
| 11. Round | 04/12/2021 | SS Cosmos | - | FC Domagnano | 0:0 |  |
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| 12. Round | 11/12/2021 | FC Domagnano | - | SP La Fiorita | 1:2 |
Italy