| 2. Round | 24/07/2022 | LD Alajuelense | - | AD Guanacasteca | 4:1 | ||||
| 3. Round | 31/07/2022 | CS Herediano | - | LD Alajuelense | 3:0 | ||||
| 4. Round | 07/08/2022 | Guadalupe | - | LD Alajuelense | 1:3 | ||||
| 5. Round | 10/08/2022 | Sporting FC | - | LD Alajuelense | 2:2 | ||||
| 6. Round | 14/08/2022 | Santos de Guápiles | - | LD Alajuelense | 2:1 | ||||
| 7. Round | 21/08/2022 | AD Guanacasteca | - | LD Alajuelense | 1:2 | ||||
| 8. Round | 29/08/2022 | LD Alajuelense | - | CS Herediano | 2:2 | ||||
| 9. Round | 01/09/2022 | LD Alajuelense | - | Guadalupe | 1:0 |  |
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| 10. Round | 04/09/2022 | LD Alajuelense | - | Sporting FC | 2:1 | ||||
| 11. Round | 11/09/2022 | LD Alajuelense | - | Deportivo Saprissa | 0:1 | |
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| 12. Round | 17/09/2022 | Puntarenas FC | - | LD Alajuelense | 0:0 | ||||
| 15. Round | 29/09/2022 | CS Cartaginés | - | LD Alajuelense | 1:2 |
Guyana