| 21. Round | 23/01/2021 | AS Nancy Lorraine | - | Chamois Niortais | 2:2 |  |
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| 22. Round | 30/01/2021 | AS Nancy Lorraine | - | Paris FC | 1:1 | ||||
| 23. Round | 02/02/2021 | Havre AC | - | AS Nancy Lorraine | 1:1 | |
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| 24. Round | 05/02/2021 | AS Nancy Lorraine | - | Pau FC | 1:0 | ||||
| 26. Round | 20/02/2021 | AS Nancy Lorraine | - | Grenoble Foot 38 | 1:2 | |
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| 27. Round | 27/02/2021 | LB Châteauroux | - | AS Nancy Lorraine | 1:4 |  |
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| 28. Round | 02/03/2021 | AS Nancy Lorraine | - | SM Caen | 1:0 | |
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| 29. Round | 13/03/2021 | ESTAC Troyes | - | AS Nancy Lorraine | 1:5 | |
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| 30. Round | 20/03/2021 | AS Nancy Lorraine | - | Clermont Foot 63 | 1:0 | ||||
| 31. Round | 03/04/2021 | Toulouse FC | - | AS Nancy Lorraine | 4:1 | ||||
| 32. Round | 10/04/2021 | AS Nancy Lorraine | - | FC Sochaux | 0:0 | ||||
| 33. Round | 17/04/2021 | AJ Auxerre | - | AS Nancy Lorraine | 3:2 | |
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| 34. Round | 20/04/2021 | AS Nancy Lorraine | - | AC Ajaccio | 2:0 | ||||
| 36. Round | 01/05/2021 | AS Nancy Lorraine | - | Valenciennes FC | 1:3 | ||||
| 37. Round | 08/05/2021 | Rodez AF | - | AS Nancy Lorraine | 1:1 | ||||
| 38. Round | 15/05/2021 | AS Nancy Lorraine | - | Amiens SC | 2:2 |
France