| 1. Round | 13/01/2022 | Municipal Pérez Zeledón | - | Municipal Grecia | 1:1 | ||||
| 2. Round | 16/01/2022 | CS Cartaginés | - | Municipal Pérez Zeledón | 2:1 | ||||
| 3. Round | 22/01/2022 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 | ||||
| 9. Round | 02/03/2022 | Municipal Pérez Zeledón | - | Guadalupe | 0:1 | ||||
| 10. Round | 08/03/2022 | Municipal Pérez Zeledón | - | Jicaral | 2:1 |  |
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| 11. Round | 01/04/2022 | CS Herediano | - | Municipal Pérez Zeledón | 3:2 | |
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| 13. Round | 11/04/2022 | Municipal Pérez Zeledón | - | CS Cartaginés | 3:0 |  |
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| 14. Round | 14/04/2022 | Municipal Pérez Zeledón | - | AD San Carlos | 1:0 | ||||
| 16. Round | 24/04/2022 | Municipal Pérez Zeledón | - | AD Guanacasteca | 2:2 | |
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| 17. Round | 27/04/2022 | Municipal Pérez Zeledón | - | Santos de Guápiles | 1:1 | ||||
| 19. Round | 05/05/2022 | Municipal Pérez Zeledón | - | Sporting FC | 0:1 | ||||
| 20. Round | 08/05/2022 | Guadalupe | - | Municipal Pérez Zeledón | 2:2 | ||||
| 22. Round | 15/05/2022 | Municipal Pérez Zeledón | - | CS Herediano | 2:3 |
Costa Rica