| 2. Round | 23/01/2021 | Atlético FC | - | Real Cartagena | 3:0 | ||||
| 3. Round | 01/02/2021 | Real Cartagena | - | Barranquilla FC | 1:0 | ||||
| 5. Round | 11/02/2021 | Real Cartagena | - | Llaneros FC | 3:1 | ||||
| 6. Round | 15/02/2021 | Unión Magdalena | - | Real Cartagena | 2:1 | ||||
| 7. Round | 19/02/2021 | Real Cartagena | - | Deportes Quindío | 2:3 | ||||
| 8. Round | 27/02/2021 | Orsomarso SC | - | Real Cartagena | 3:3 | ||||
| 9. Round | 03/03/2021 | Real Cartagena | - | Boca Juniors de Cali | 1:1 | ||||
| 11. Round | 14/03/2021 | Real Santander | - | Real Cartagena | 0:3 |
Colombia