| 1. Round | 22/01/2023 | Matagalpa FC | - | Diriangén FC | 0:3 |  |
|||
| 2. Round | 30/01/2023 | ART Municipal Jalapa | - | Matagalpa FC | 1:1 |  |
|
||
| 3. Round | 05/02/2023 | Matagalpa FC | - | Juventus Managua | 1:0 | |
|||
| 4. Round | 09/02/2023 | H&H Export Sébaco | - | Matagalpa FC | 0:3 | |
|||
| 5. Round | 12/02/2023 | Matagalpa FC | - | Club Deportivo Ocotal | 2:0 | |
|||
| 9. Round | 05/03/2023 | Real Estelí FC | - | Matagalpa FC | 2:1 | ||||
| 10. Round | 10/03/2023 | Diriangén FC | - | Matagalpa FC | 2:1 | ||||
| 11. Round | 19/03/2023 | Matagalpa FC | - | ART Municipal Jalapa | 1:2 | ||||
| 12. Round | 25/03/2023 | Juventus Managua | - | Matagalpa FC | 2:2 | ||||
| 13. Round | 01/04/2023 | Matagalpa FC | - | H&H Export Sébaco | 0:0 | |
|||
| 14. Round | 05/04/2023 | Club Deportivo Ocotal | - | Matagalpa FC | 0:1 | |
|||
| 15. Round | 12/04/2023 | Matagalpa FC | - | CD Walter Ferretti | 1:0 | ||||
| 16. Round | 15/04/2023 | UNAN Managua | - | Matagalpa FC | 3:1 | |
|||
| 18. Round | 23/04/2023 | Matagalpa FC | - | Real Estelí FC | 0:1 |
Nicaragua