| 1. Round | 19/01/2025 | Matagalpa FC | - | Diriangén FC | 0:4 | ||||
| 3. Round | 26/01/2025 | Real Estelí FC | - | Matagalpa FC | 2:0 |  |
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| 7. Round | 16/02/2025 | Managua FC | - | Matagalpa FC | 1:0 | ||||
| 8. Round | 19/02/2025 | Matagalpa FC | - | UNAN Managua | 2:2 | ||||
| 9. Round | 22/02/2025 | Matagalpa FC | - | ART Municipal Jalapa | 3:3 | ||||
| 4. Round | 26/02/2025 | Matagalpa FC | - | Rancho Santana | 2:1 | ||||
| 10. Round | 03/03/2025 | Diriangén FC | - | Matagalpa FC | 3:1 | ||||
| 11. Round | 08/03/2025 | Matagalpa FC | - | Club Deportivo Ocotal | 3:0 | ||||
| 12. Round | 12/03/2025 | Matagalpa FC | - | Real Estelí FC | 2:4 |  |
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| 13. Round | 23/03/2025 | Rancho Santana | - | Matagalpa FC | 1:1 | ||||
| 14. Round | 30/03/2025 | Matagalpa FC | - | H&H Export Sébaco | 5:2 | ||||
| 15. Round | 08/04/2025 | CD Walter Ferretti | - | Matagalpa FC | 0:0 | ||||
| 17. Round | 27/04/2025 | UNAN Managua | - | Matagalpa FC | 1:1 | ||||
| 18. Round | 02/05/2025 | ART Municipal Jalapa | - | Matagalpa FC | 3:0 |
Nicaragua