| 1. Round | 01/08/2021 | CD Walter Ferretti | - | Real Madriz | 4:1 | ||||
| 3. Round | 16/08/2021 | Real Madriz | - | Juventus Managua | 2:0 | ||||
| 4. Round | 23/08/2021 | UNAN Managua | - | Real Madriz | 3:5 | ||||
| 10. Round | 02/10/2021 | Real Madriz | - | CD Walter Ferretti | 3:1 | ||||
| 14. Round | 25/10/2021 | Real Madriz | - | Club Deportivo Ocotal | 1:1 | ||||
| 15. Round | 01/11/2021 | ART Municipal Jalapa | - | Real Madriz | 0:1 |  |
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| 17. Round | 18/11/2021 | Real Madriz | - | Managua FC | 1:3 |
Nicaragua