| 2. Round | 16/01/2021 | FC Juárez | - | Club Tijuana | 0:0 | ||||
| 3. Round | 27/01/2021 | CF América | - | FC Juárez | 2:0 | ||||
| 6. Round | 13/02/2021 | Puebla FC | - | FC Juárez | 4:0 | ||||
| 8. Round | 01/03/2021 | Santos Laguna | - | FC Juárez | 3:2 | ||||
| 9. Round | 04/03/2021 | FC Juárez | - | CF Monterrey | 1:6 | ||||
| 10. Round | 06/03/2021 | Atlas Guadalajara | - | FC Juárez | 2:0 | ||||
| 11. Round | 13/03/2021 | FC Juárez | - | Pumas UNAM | 1:1 | ||||
| 13. Round | 03/04/2021 | FC Juárez | - | Cruz Azul | 0:1 | ||||
| 14. Round | 10/04/2021 | FC Juárez | - | Atlético San Luis | 2:1 | ||||
| 5. Round | 15/04/2021 | FC Juárez | - | UANL Tigres | 2:3 |  |
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| 15. Round | 20/04/2021 | Club León | - | FC Juárez | 2:0 | ||||
| 16. Round | 26/04/2021 | Gallos Blancos | - | FC Juárez | 1:0 | ||||
| 17. Round | 01/05/2021 | FC Juárez | - | Deportivo Toluca | 1:0 |
Colombia