| 1. Round | 16/08/2021 | Gżira United | - | Hibernians FC | 1:3 | ||||
| 2. Round | 22/08/2021 | Hibernians FC | - | Gudja United | 2:1 | ||||
| 3. Round | 12/09/2021 | Sirens FC | - | Hibernians FC | 1:3 | ||||
| 4. Round | 18/09/2021 | Hibernians FC | - | Mosta FC | 3:2 | ||||
| 5. Round | 25/09/2021 | Hibernians FC | - | St. Luċija FC | 1:1 |  |
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| 6. Round | 17/10/2021 | Sliema Wanderers | - | Hibernians FC | 0:3 | ||||
| 7. Round | 24/10/2021 | Hibernians FC | - | Valletta FC | 1:1 | ||||
| 8. Round | 30/10/2021 | Birkirkara FC | - | Hibernians FC | 1:1 | ||||
| 9. Round | 21/11/2021 | Hibernians FC | - | Hamrun Spartans | 1:0 | ||||
| 10. Round | 28/11/2021 | Balzan FC | - | Hibernians FC | 1:2 | ||||
| 12. Round | 12/12/2021 | Hibernians FC | - | Gżira United | 3:1 | ||||
| 13. Round | 19/12/2021 | Gudja United | - | Hibernians FC | 1:2 | ||||
| 14. Round | 18/01/2022 | Hibernians FC | - | Sirens FC | 1:1 | ||||
| 15. Round | 22/01/2022 | Mosta FC | - | Hibernians FC | 1:1 |  |
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| 16. Round | 29/01/2022 | St. Luċija FC | - | Hibernians FC | 0:0 | ||||
| 18. Round | 12/02/2022 | Valletta FC | - | Hibernians FC | 1:4 | ||||
| 22. Round | 12/03/2022 | Floriana FC | - | Hibernians FC | 1:4 |
Malta