| 1. Round | 21/08/2021 | KVC Westerlo [U18] | - | SV Zulte Waregem [U18] | 0:1 |  |
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| 2. Round | 28/08/2021 | KAA Gent [U18] | - | KVC Westerlo [U18] | 3:2 | ||||
| 3. Round | 04/09/2021 | KVC Westerlo [U18] | - | Sporting Charleroi [U18] | 3:3 | ||||
| 6. Round | 25/09/2021 | Cercle Brugge [U18] | - | KVC Westerlo [U18] | 2:0 | ||||
| 12. Round | 13/11/2021 | KVC Westerlo [U18] | - | Sint-Truidense VV [U18] | 0:2 | |
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| 13. Round | 20/11/2021 | Club Brugge KV [U18] | - | KVC Westerlo [U18] | 4:2 | |
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| 18. Round | 05/02/2022 | SV Zulte Waregem [U18] | - | KVC Westerlo [U18] | 2:0 | ||||
| 19. Round | 12/02/2022 | KVC Westerlo [U18] | - | Cercle Brugge [U18] | 2:2 | |
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| 23. Round | 19/03/2022 | KV Mechelen [U18] | - | KVC Westerlo [U18] | 3:1 | ||||
| 24. Round | 26/03/2022 | KVC Westerlo [U18] | - | RSC Anderlecht [U18] | 2:3 |
Belgium