| 4. Round | 12/09/2021 | Sparta Rotterdam | - | Fortuna Sittard | 3:1 | ||||
| 5. Round | 18/09/2021 | sc Heerenveen | - | Fortuna Sittard | 1:0 |  |
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| 6. Round | 21/09/2021 | Fortuna Sittard | - | AFC Ajax | 0:5 | ||||
| 7. Round | 25/09/2021 | Vitesse | - | Fortuna Sittard | 1:1 | |
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| 8. Round | 02/10/2021 | Fortuna Sittard | - | NEC Nijmegen | 1:3 | ||||
| 9. Round | 16/10/2021 | Fortuna Sittard | - | SC Cambuur | 1:0 | ||||
| 10. Round | 22/10/2021 | Willem II | - | Fortuna Sittard | 1:1 | ||||
| 11. Round | 31/10/2021 | Go Ahead Eagles | - | Fortuna Sittard | 4:3 |
Germany
England