| 1. Round | 17/10/2021 | US Tataouine | - | CA Bizertin | 2:1 | ||||
| 2. Round | 23/10/2021 | CA Bizertin | - | ES Hammam Sousse | 0:0 | ||||
| 4. Round | 03/11/2021 | CS Hammam-Lif | - | CA Bizertin | 0:1 | ||||
| 5. Round | 06/11/2021 | CA Bizertin | - | ES Métlaoui | 1:0 | ||||
| 8. Round | 19/02/2022 | CA Bizertin | - | US Tataouine | 0:1 | ||||
| 9. Round | 26/02/2022 | ES Hammam Sousse | - | CA Bizertin | 1:0 | ||||
| 10. Round | 09/03/2022 | Espérance de Tunis | - | CA Bizertin | 4:0 | ||||
| 12. Round | 06/04/2022 | ES Métlaoui | - | CA Bizertin | 2:1 | ||||
| 13. Round | 10/04/2022 | CA Bizertin | - | CS Sfaxien | 2:0 | ||||
| 14. Round | 18/04/2022 | US Ben Guerdane | - | CA Bizertin | 0:1 |
Tunisia