| 1. Round | 24/01/2020 | Deportes Tolima | - | Independiente Medellín | 2:2 | ||||
| 2. Round | 28/01/2020 | Independiente Medellín | - | Águilas Doradas | 2:1 |  |
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| 3. Round | 01/02/2020 | Atlético Junior | - | Independiente Medellín | 1:0 | ||||
| 4. Round | 07/02/2020 | Independiente Medellín | - | Patriotas FC | 3:1 | ||||
| 6. Round | 22/02/2020 | Independiente Medellín | - | Atlético Nacional | 1:3 | ||||
| 8. Round | 07/03/2020 | Independiente Medellín | - | Millonarios | 1:0 | ||||
| 9. Round | 20/09/2020 | Alianza Petrolera | - | Independiente Medellín | 1:0 | ||||
| 10. Round | 28/09/2020 | Independiente Medellín | - | Deportivo Pereira | 1:1 |  |
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| 11. Round | 05/10/2020 | La Equidad | - | Independiente Medellín | 1:0 | ||||
| 12. Round | 09/10/2020 | Independiente Medellín | - | Cúcuta Deportivo | 4:1 | |
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| 13. Round | 11/10/2020 | Boyacá Chicó | - | Independiente Medellín | 1:0 | |
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| 14. Round | 15/10/2020 | Independiente Medellín | - | Jaguares de Córdoba | 1:1 | ||||
| 19. Round | 10/11/2020 | Independiente Medellín | - | Atlético Bucaramanga | 1:0 | ||||
| 20. Round | 14/11/2020 | Envigado FC | - | Independiente Medellín | 2:1 | |
Colombia