| 4. Round | 31/08/2021 | Cardiff Metropolitan | - | Penybont FC | 3:2 | ||||
| 6. Round | 18/09/2021 | Cefn Druids | - | Penybont FC | 0:3 | ||||
| 7. Round | 02/10/2021 | Penybont FC | - | Caernarfon Town | 1:1 | ||||
| 8. Round | 09/10/2021 | Newtown AFC | - | Penybont FC | 3:1 | ||||
| 9. Round | 12/10/2021 | Penybont FC | - | Haverfordwest County | 2:1 | ||||
| 10. Round | 22/10/2021 | Aberystwyth Town | - | Penybont FC | 0:3 | ||||
| 12. Round | 06/11/2021 | Flint Town United | - | Penybont FC | 3:1 | ||||
| 13. Round | 09/11/2021 | Penybont FC | - | Cardiff Metropolitan | 2:1 | ||||
| 14. Round | 20/11/2021 | Connah's Quay Nomads | - | Penybont FC | 0:0 | ||||
| 15. Round | 04/12/2021 | Caernarfon Town | - | Penybont FC | 1:2 | ||||
| 17. Round | 18/12/2021 | The New Saints | - | Penybont FC | 3:2 | ||||
| 20. Round | 21/01/2022 | Penybont FC | - | Aberystwyth Town | 4:0 |  |
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| 21. Round | 28/01/2022 | Haverfordwest County | - | Penybont FC | 2:2 | |
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| 18. Round | 04/02/2022 | Penybont FC | - | Barry Town United | 4:0 | ||||
| 19. Round | 11/02/2022 | Barry Town United | - | Penybont FC | 0:0 |
Wales