| 3. Round | 11/09/2021 | Orlando Pirates | - | Moroka Swallows | 1:0 | ||||
| 4. Round | 18/09/2021 | Chippa United | - | Orlando Pirates | 1:3 | ||||
| 19. Round | 24/11/2021 | Stellenbosch FC | - | Orlando Pirates | 0:3 | ||||
| 13. Round | 02/12/2021 | Orlando Pirates | - | Baroka FC | 0:0 |  |
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| 14. Round | 08/12/2021 | AmaZulu FC | - | Orlando Pirates | 1:1 | ||||
| 15. Round | 11/12/2021 | Orlando Pirates | - | TS Galaxy | 2:0 | ||||
| 16. Round | 17/12/2021 | Mamelodi Sundowns | - | Orlando Pirates | 4:1 | ||||
| 17. Round | 20/12/2021 | Orlando Pirates | - | Marumo Gallants | 2:1 | ||||
| 23. Round | 23/12/2021 | Orlando Pirates | - | AmaZulu FC | 2:1 | ||||
| 21. Round | 05/03/2022 | Orlando Pirates | - | Kaizer Chiefs | 1:2 | ||||
| 29. Round | 24/05/2022 | Orlando Pirates | - | Maritzburg United | 4:1 | |
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| 28. Round | 27/05/2022 | Royal AM | - | Orlando Pirates | 2:2 | |
South Africa