| 4. Round | 21/08/2010 | Lierse SK (old) | - | KV Kortrijk | 1:2 | ||||
| 5. Round | 29/08/2010 | KRC Genk | - | Lierse SK (old) | 4:1 |  |
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| 6. Round | 11/09/2010 | Lierse SK (old) | - | KAA Gent | 2:2 | ||||
| 7. Round | 18/09/2010 | KVC Westerlo | - | Lierse SK (old) | 2:0 | ||||
| 8. Round | 22/09/2010 | Lierse SK (old) | - | RSC Anderlecht | 1:1 | ||||
| 12. Round | 23/10/2010 | Lierse SK (old) | - | SV Zulte Waregem | 0:0 | ||||
| 13. Round | 30/10/2010 | KAS Eupen | - | Lierse SK (old) | 2:2 | ||||
| 14. Round | 06/11/2010 | Lierse SK (old) | - | Sporting Lokeren | 2:2 |
France