| 1. Round | 10/07/2022 | H&H Export Sébaco | - | Juventus Managua | 0:0 | ||||
| 2. Round | 17/07/2022 | Juventus Managua | - | Managua FC | 2:1 | ||||
| 3. Round | 24/07/2022 | Juventus Managua | - | Matagalpa FC | 3:2 | ||||
| 4. Round | 31/07/2022 | Diriangén FC | - | Juventus Managua | 2:0 | ||||
| 5. Round | 08/08/2022 | Juventus Managua | - | Real Estelí FC | 0:0 | ||||
| 6. Round | 12/08/2022 | UNAN Managua | - | Juventus Managua | 2:1 | ||||
| 7. Round | 14/08/2022 | Juventus Managua | - | CD Walter Ferretti | 0:1 | ||||
| 8. Round | 22/08/2022 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | ||||
| 10. Round | 04/09/2022 | Juventus Managua | - | H&H Export Sébaco | 1:1 | ||||
| 11. Round | 12/09/2022 | Managua FC | - | Juventus Managua | 3:0 | ||||
| 12. Round | 01/10/2022 | Matagalpa FC | - | Juventus Managua | 2:5 | ||||
| 13. Round | 23/10/2022 | Juventus Managua | - | Diriangén FC | 2:4 |  |
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| 14. Round | 27/10/2022 | Real Estelí FC | - | Juventus Managua | 2:1 | ||||
| 15. Round | 31/10/2022 | Juventus Managua | - | UNAN Managua | 2:1 | ||||
| 16. Round | 13/11/2022 | CD Walter Ferretti | - | Juventus Managua | 2:1 | |
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| 18. Round | 30/11/2022 | Juventus Managua | - | Club Deportivo Ocotal | 9:0 |
Mexico