| 2. Round | 11/09/2021 | Ethnikos Achna | - | PAEEK | 1:3 | ||||
| 3. Round | 17/09/2021 | PAEEK | - | Aris Limassol | 0:0 | ||||
| 4. Round | 27/09/2021 | APOEL Nikosia | - | PAEEK | 1:0 | ||||
| 5. Round | 01/10/2021 | PAEEK | - | AEL Limassol | 1:3 | ||||
| 6. Round | 16/10/2021 | AEK Larnaca | - | PAEEK | 3:0 | ||||
| 7. Round | 25/10/2021 | PAEEK | - | Omonia Nikosia | 1:0 |  |
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| 8. Round | 01/11/2021 | Paphos FC | - | PAEEK | 2:0 | ||||
| 9. Round | 05/11/2021 | PAEEK | - | Olympiakos Nikosia | 0:0 | ||||
| 10. Round | 22/11/2021 | Apollon Limassol | - | PAEEK | 3:1 | ||||
| 11. Round | 27/11/2021 | PAEEK | - | Doxa Katokopias | 1:2 | ||||
| 12. Round | 04/12/2021 | Anorthosis Famagusta | - | PAEEK | 2:3 | |
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| 13. Round | 11/12/2021 | PAEEK | - | Ethnikos Achna | 0:2 | ||||
| 14. Round | 17/12/2021 | Aris Limassol | - | PAEEK | 1:1 | ||||
| 1. Round | 22/12/2021 | PAEEK | - | Anorthosis Famagusta | 0:2 |
Netherlands